| First game, first win | 7-2 @ Baltimore (Plate umpire Johnny Stevens, Game time 2:33) | 4/11/61 |
| First loss | 3-0 @ Boston | 4/15/61 |
| First home game | 4-2 loss vs. Minnesota | 4/27/61 |
| First home win | 6-5, 12 innings, vs. Minnesota | 4/28/61 |
| First winning pitcher | Eli Grba (7-2 @ Baltimore) | 4/11/61 |
| First losing pitcher | Jerry Casale (3-0 @ Boston) | 4/15/61 |
| First complete game | Eli Grba @ Baltimore | 4/11/61 |
| First pitch | Eli Grba, strike to Baltimore's Jackie Brandt | 4/11/61 |
| First wild pitch | Eli Grba (6th inn @ Baltimore) | 4/11/61 |
| First strikeout | Eli Grba @ Baltimore (Jackie Brandt, 5th inning) | 4/11/61 |
| First walk allowed | Eli Grba @ Baltimore (Gene Stephens, 2nd inning) | 4/11/61 |
| First hit batter | Ted Bowsfield vs. Baltimore (5th inning, hitting Jerry Adair) | 5/2/61 |
| First home run allowed | Tom Morgan @ Boston, (7th inning, hit by Gary Geiger) | 4/17/61 |
| First save | Tom Morgan, vs. Kansas City | 4/30/61 |
| First hit | Ted Kluszewski, HR @ Baltimore | 4/11/61 |
| First walk | Albie Pearson @ Baltimore, (1st inning, hit off Milt Pappas) | 4/11/61 |
| First single | Albie Pearson @ Baltimore, (2nd inning, hit off Milt Pappas) | 4/11/61 |
| First bunt single | Albie Pearson @ Boston, 6th inning | 4/15/61 |
| First double | Ken Hunt @ Boston, 3rd inn | 4/17/61 |
| First triple | Ken Hunt, @ New York Yankees (2nd game) | 4/20/61 |
| First home run | Ted Kluszewski @ Baltimore (1st inning, hit off Milt Pappas) | 4/11/61 |
| First solo home run | Bob Cerv @ Baltimore (1st inning, hit off Milt Pappas) | 4/11/61 |
| First two-run home run | Ted Kluszewski @ Baltimore (1st inning, hit off Milt Pappas) | 4/11/61 |
| First three-run home run | Ted Kluszewski @ Baltimore (2nd inning, hit off John Papa) | 4/11/61 |
| First grand slam | Lee Thomas @ Baltimore (2st inning, hit off Milt Pappas) | 6/6/61 |
| First two-home run game | Ted Kluzewski @ Baltimore | 4/11/61 |
| First three-home run game | Lee Thomas @ Kansas City (hit off Lew Krausse, Ed Rakow & Bill Fischer) | 9/5/61 |
| First pinch home run | Albie Pearson @ Boston (9th inning, hit off Mike Fornieles) | 4/17/61 |
| First home run by a pitcher | Jerry Casale, vs. Boston (2nd inning, hit off Ike Delock) | 5/9/61 |
| First extra-base hit | Ted Kluszewski, HR @ Baltimore | 4/11/61 |
| First RBI | Ted Kluszewsk @ Baltimore | 4/11/61 |
| First run | Albie Pearson @ Baltimore | 4/11/61 |
| First extra-inning game | 3-2 loss, 11 innings, @ Detroit | 4/23/61 |
| First extra-inning win | 6-5, 12 innings vs. Minnesota | 4/28/61 |
| First ejection | Ed Yost @ Boston | 4/15/61 |
| First putout | Fritz Bickell @ Baltimore | 4/11/61 |
| First error | Fritz Bickell @ Baltimore | 4/11/61 |
| First no-hitter | Bo Belinsky, vs. Baltimore | 5/5/62 |
